Michelangelo has been impressed by the massive scale of the work and its sensuous Hellenistic aesthetic, particularly its depiction of male figures. The sculpture Laocoön and His Sons had a profound effect on the development of Michelangelo's style. Its influence, as well as the Belvedere Torso, is evidenced in many of Michelangelo's sculptures, such as the Rebellious Slave and the Dying Slave sculpted for the tomb of Pope Julius II, both of which are restrained and encircled by straps around their naked bodies.
Art historians have suggested that there are references to the sculpture Laocoön and His Sons in the Sistine Chapel. Several of the nude males and the figure of Haman in the Sistine Chapel ceiling draw on the figures Michelangelo adapted the form and type of the Laocoön and His Sons for the central Christ group in the Last Judgment. Minos, the Judge of the Underworld in the Last Judgement has a snake provocatively wrapped around him.